A simple PRR Analysis of COVID-19 vaccines

A list of safety signals, as announced by the CDC a long time ago.

Summary

For this article I performed a full proportional reporting ratio (PRR) analysis for COVID-19 vaccines based on US VAERS reports. This type of analysis helps researchers spot safety signals inside pharmacovigilance systems.

There were 1,926 hits for potential safety signals with reporting ratios of 1.1 or higher in reports for COVID-19 vaccines compared to reports for other vaccines.

The full list of results sorted by System Organ Class can be found in the Results section at the end of this article. I also supply links to CSV and PDF files which contain the results.

The MedDRA terms with the highest PRR’s were:

149.7 Vaccination site lymphadenopathy
115.5 Postmenopausal haemorrhage
104.6 Prohormone brain natriuretic peptide increased
68.2 Lung opacity
66.8 Left ventricular failure
57.7 Disease recurrence
54.2 Acute respiratory failure
50.7 Cerebral venous sinus thrombosis
48.3 Angiogram pulmonary abnormal
48.3 Vaccine breakthrough infection
44.6 Vaccination site pruritus
35.6 Anosmia
29.9 Polymenorrhoea
26.6 Pulmonary thrombosis

Introduction

On January 29th 2021 the CDC released a document in which they announced “CDC will perform Proportional Reporting Ratio (PRR) analysis (see section 2.3.1, p. 14), excluding laboratory results, to identify AEs that are disproportionately reported”.

They might have performed such an analysis, but the results were never presented to the public, which is why I decided to take up their job, albeit a bit late. I will even include the laboratory results.

I think that this extensive PRD analysis for various subsamples against age- and gender-adjusted pseudo-placebo reference groups is much more useful to both patients and doctors than a simple PRR, but we will start with the simplest version and then work our way towards a more complex analysis.

Methods

All my VAERS searches are run on the US subsample of the data due to inconsistencies in the reporting behaviour of foreign regulatory agencies.

Since I regularly perform age- and gender-adjustment on all subsamples in order to compare the distribution of side effects between the, I run a simple Regular Expression on the SYMPTOMS_TEXT field to determine the patient age in those reports that do not have the age fields populated by the CDC:
/\W(\d{1,3})\W*ye*a*rs*\W*old$/i

If the age can not be determined, the report is dropped.

I then split the dataset into two parts:

1. Study group: All reports about patients who received only a COVID-19 vaccine

2. Control group: All reports about patients who did not receive a COVID-19 vaccine

Now we count all occurences of every MedDRA term.

For every term we calculate the proportion of reports that contains them and calculate the proportional reporting ratio:

PR(study) = x(study) / n(study)

PR(control) = x(control) / n(control)

PRR = PR(study) / PR(control)

I then group the results by the following MedDRA System Organ Classes (SOC’s) with the help of bioontology.org:

• Immune system disorders

• Skin and subcutaneous tissue disorders

• Infections and infestations

• Nervous system disorders

• Metabolism and nutrition disorders

• Psychiatric disorders

• General disorders and administration site conditions

• Musculoskeletal and connective tissue disorders

• Respiratory, thoracic and mediastinal disorders

• Renal and urinary disorders

• Reproductive system and breast disorders

• Investigations

• Vascular disorders

• Eye disorders

• Blood and lymphatic system disorders

• Injury, poisoning and procedural complications

• Hepatobiliary disorders

• Endocrine disorders

• Neoplasms benign, malignant and unspecified (incl cysts and polyps)

• Gastrointestinal disorders

• Pregnancy, puerperium and perinatal conditions

• Cardiac disorders

• Ear and labyrinth disorders

In the CSV version of the results you will also find both the 95% confidence intervals for the PRR, as well as the PRD (proportional reporting difference) and its 95% confidence interval.

In the PDF version you will find a plain list of results with their PRR’s, sorted by SOC.

I decided to move the Discussion section above the Results section since the latter is a list of 1,926 unique terms and their PRR’s of which many are listed in multiple categories which makes it a very long section.

Discussion

The PRR analysis you see in the article has the following weaknesses:

1. The age and gender structure of our two subsamples differs (solved by age and gender adjustment)

2. The PRR swallows information about the frequency at which a term occured in the two subsamples (solved by using the PRD instead, proportional reporting difference)

3. MedDRA is subject to changes over time

Results

Immune system disorders

20.0 Multisystem inflammatory syndrome in children
17.6 Multisystem inflammatory syndrome
16.6 Chronic spontaneous urticaria
14.8 Mechanical urticaria
13.7 Immune-mediated adverse reaction
13.2 Vaccination site urticaria
13.0 Urticarial vasculitis
13.0 Myasthenia gravis crisis
11.5 Endocrine ophthalmopathy
11.5 Vaccination site hypersensitivity
11.1 Cytokine storm
7.6 Idiopathic pulmonary fibrosis
7.6 Orbital swelling
6.9 Subacute inflammatory demyelinating polyneuropathy
6.5 Heparin-induced thrombocytopenia
6.5 Interstitial lung disease
6.2 Circumoral swelling
6.0 Psoriatic arthropathy
6.0 Immunodeficiency
5.9 IgA nephropathy
5.6 Skin sensitisation
5.6 Episcleritis
5.4 Urticaria chronic
5.3 Immunosuppression
5.0 Polychondritis
4.8 Periorbital swelling
4.8 Drug reaction with eosinophilia and systemic symptoms
4.6 Urticaria cholinergic
4.6 Allergic sinusitis
4.6 Acute respiratory distress syndrome
4.1 Mouth swelling
4.0 Swelling of eyelid
3.8 Chronic gastritis
3.6 Systemic inflammatory response syndrome
3.6 Psoriasis
3.4 Glomerulonephritis rapidly progressive
3.3 Basedow's disease
3.0 Ankylosing spondylitis
2.9 Colitis ulcerative
2.9 Crohn's disease
2.8 Giant cell arteritis
2.7 Antiphospholipid syndrome
2.7 Transplant rejection
2.6 Vitiligo
2.6 Eosinophilic oesophagitis
2.6 Still's disease
2.6 Myasthenia gravis
2.6 Type IV hypersensitivity reaction
2.5 Pemphigus
2.4 Mast cell activation syndrome
2.4 Seasonal allergy
2.4 Allergy to arthropod bite
2.3 Swollen tongue
2.3 Guttate psoriasis
2.3 Allergy to arthropod sting
2.2 Pemphigoid
2.2 Injection related reaction
2.0 Alopecia areata
2.0 Immunisation reaction
2.0 Cystitis interstitial
1.9 Allergy to chemicals
1.9 Butterfly rash
1.9 Autoimmune hepatitis
1.8 Haemophagocytic lymphohistiocytosis
1.7 Sjogren's syndrome
1.7 Arthritis reactive
1.6 Rheumatoid arthritis
1.6 Autoimmune thyroiditis
1.6 Autoimmune haemolytic anaemia
1.5 Polymyalgia rheumatica
1.5 Lip swelling
1.3 Dermatitis allergic
1.3 Swelling face
1.1 Anaphylactic reaction

Cardiac disorders

81.7 Acute left ventricular failure
66.8 Left ventricular failure
55.0 Agonal respiration
38.2 Left ventricular dilatation
38.2 Cardiovascular symptom
31.3 Right ventricular dysfunction
29.4 Cardiac dysfunction
29.0 Cardiac failure chronic
25.2 Dyspnoea paroxysmal nocturnal
25.2 Heart valve incompetence
25.2 Acute cardiac event
21.8 Intracardiac thrombus
19.9 Left atrial enlargement
17.9 Arteriosclerosis coronary artery
17.8 Acute myocardial infarction
17.2 Acute pulmonary oedema
16.6 Diastolic dysfunction
15.3 Atrial enlargement
14.9 Heart injury
14.1 Dyspnoea at rest
14.0 Coronary artery dissection
13.5 Acute coronary syndrome
13.3 Bundle branch block left
13.2 Cardiac discomfort
13.0 Ventricular dysfunction
12.9 Left ventricular dysfunction
12.5 Systolic dysfunction
12.2 Coronary artery thrombosis
12.2 Right atrial enlargement
12.2 Cardiac flutter
11.8 Hypertensive heart disease
11.5 Dyspnoea exertional
11.1 Cardiogenic shock
11.1 Left ventricular hypertrophy
11.1 Coronary artery stenosis
10.9 Left atrial dilatation
10.7 Sinus node dysfunction
10.7 Ventricular hypertrophy
10.3 Right atrial dilatation
9.9 Coronary artery occlusion
9.9 Torsade de pointes
9.7 Ventricular hypokinesia
9.7 Myocardial oedema
9.3 Atrioventricular block first degree
8.8 Stress cardiomyopathy
8.4 Nodal arrhythmia
8.4 Ventricular enlargement
8.3 Aortic valve incompetence
8.2 Tricuspid valve incompetence
8.2 Carditis
7.9 Atrial fibrillation
7.6 Cardiac death
7.6 Extrasystoles
7.3 Angina pectoris
7.3 Atrial flutter
7.0 Supraventricular extrasystoles
6.9 Bicuspid aortic valve
6.8 Mitral valve incompetence
6.4 Dizziness exertional
6.3 Atrioventricular block complete
6.1 Microvascular coronary artery disease
6.1 Bundle branch block right
6.0 Ventricular extrasystoles
6.0 Orthopnoea
6.0 Cardiac failure congestive
5.8 Angina unstable
5.4 Cardiomegaly
5.3 Sinus tachycardia
5.2 Cardiac tamponade
5.1 Atrial tachycardia
5.0 Pericardial effusion
4.9 Ventricular tachycardia
4.8 Atrioventricular block second degree
4.8 Myocarditis
4.6 Myocardial infarction
4.6 Supraventricular tachycardia
4.4 Myocardial ischaemia
4.3 Cardiac disorder
4.3 Tachyarrhythmia
4.1 Palpitations
4.0 Fluid overload
4.0 Ventricular fibrillation
4.0 Sinus arrhythmia
3.9 Cardiac failure
3.8 Tachycardia foetal
3.8 Foetal cardiac disorder
3.7 Congestive cardiomyopathy
3.7 Pericarditis
3.6 Sinus arrest
3.6 Right ventricular hypertrophy
3.5 Atrioventricular block
3.4 Cor pulmonale
3.2 Cardio-respiratory arrest
3.2 Myocardial fibrosis
3.2 Sudden cardiac death
3.1 Mitral valve disease
3.0 Chest discomfort
2.9 Hypertrophic cardiomyopathy
2.9 Ventricular arrhythmia
2.8 Chest pain
2.8 Haemoptysis
2.8 Arrhythmia
2.7 Mitral valve prolapse
2.7 Coronary artery disease
2.6 Sinus bradycardia
2.6 Viral myocarditis
2.5 Arteriospasm coronary
2.5 Dizziness postural
2.4 Ascites
2.4 Endocarditis
2.3 Pulmonary oedema
2.3 Pulmonary congestion
2.1 Tachycardia
2.1 Aortic valve stenosis
2.1 Sudden death
2.1 Atrial septal defect
2.1 Dyspnoea
2.0 Cardiac valve disease
1.8 Cardiac arrest
1.8 Dizziness
1.7 Presyncope
1.6 Cardiomyopathy
1.2 Peripheral swelling

Infections and infestations

48.3 Vaccine breakthrough infection
26.7 Escherichia bacteraemia
23.7 Enterococcal infection
20.0 Multisystem inflammatory syndrome in children
19.9 Epstein-Barr virus infection reactivation
17.6 Multisystem inflammatory syndrome
16.8 Herpes simplex reactivation
13.0 Pneumonia bacterial
12.2 Appendicitis
11.8 Klebsiella infection
11.5 Anal abscess
10.7 Bacteriuria
10.7 Gingival abscess
10.3 Diverticulitis
10.2 Superinfection
9.9 Breast cellulitis
9.9 Asymptomatic bacteriuria
9.9 Peritonitis bacterial
9.9 Cholecystitis infective
9.6 Appendicitis perforated
9.2 Sweating fever
8.4 Pulpitis dental
8.4 Enterobacter infection
8.0 Herpes zoster reactivation
8.0 Thyroiditis subacute
7.9 Clostridium difficile infection
7.6 Septic shock
7.6 Gastric infection
7.6 Septic encephalopathy
7.6 Aspergillus infection
6.9 Cavernous sinus thrombosis
6.9 Pneumonia legionella
6.9 Rocky mountain spotted fever
6.9 Post procedural infection
6.9 Subacute inflammatory demyelinating polyneuropathy
6.1 Eye infection bacterial
6.1 Lung abscess
6.1 Staphylococcal bacteraemia
6.1 Infected cyst
6.1 Viral sepsis
6.1 Colonic abscess
6.1 Pneumonia viral
5.7 Severe acute respiratory syndrome
5.7 Gangrene
5.5 Device related infection
5.3 Eyelid infection
5.3 Intervertebral discitis
5.3 Infectious pleural effusion
5.3 Postoperative wound infection
5.2 Clostridium difficile colitis
5.0 Pseudomonas infection
4.9 Hordeolum
4.6 Abdominal infection
4.3 Pneumocystis jirovecii pneumonia
4.2 Creutzfeldt-Jakob disease
4.2 Enterococcal bacteraemia
4.2 Bacterial sepsis
4.2 Nasal herpes
3.8 Chronic gastritis
3.8 Abscess intestinal
3.8 Bacterial disease carrier
3.8 Gastroenteritis Escherichia coli
3.8 Urinary tract infection bacterial
3.7 Atypical pneumonia
3.7 Pneumonia staphylococcal
3.6 Empyema
3.6 Staphylococcal sepsis
3.5 Urosepsis
3.4 Tooth abscess
3.3 Vestibular neuronitis
3.2 Wound infection
3.1 Coronavirus infection
3.1 Body tinea
3.1 Tooth infection
3.0 Mastitis
3.0 Escherichia infection
2.9 Sputum purulent
2.8 Bacteraemia
2.7 Food poisoning
2.6 Viral myocarditis
2.5 Vulvovaginal mycotic infection
2.5 Peritonitis
2.5 Post viral fatigue syndrome
2.5 Kidney infection
2.4 Endocarditis
2.3 Cystitis
2.2 Nasopharyngitis
2.2 Pyuria
2.1 Urinary tract infection
2.1 Lower respiratory tract infection
1.9 Pustule
1.8 Chronic sinusitis
1.7 Arthritis reactive
1.7 Sepsis
1.6 Acute sinusitis
1.6 Oral herpes
1.5 Genital herpes
1.4 Eye infection
1.4 Oral candidiasis
1.4 Herpes virus infection
1.3 Pneumonia
1.2 Sinusitis

Nervous system disorders

60.3 Cerebellar stroke
50.7 Cerebral venous sinus thrombosis
50.4 Vaccination site hypoaesthesia
38.6 Cerebral artery occlusion
35.6 Anosmia
34.0 Embolic stroke
33.6 Carotid artery thrombosis
33.6 Freezing phenomenon
28.1 Cerebral thrombosis
26.0 Taste disorder
24.4 Lacunar infarction
23.7 Brain stem infarction
23.7 Cerebral artery stenosis
22.9 Cerebral small vessel ischaemic disease
22.1 Cerebral artery thrombosis
21.4 Vestibular migraine
20.6 Thalamic infarction
19.1 Eyelid sensory disorder
19.1 Basal ganglia haemorrhage
19.1 Dental paraesthesia
18.3 Metabolic encephalopathy
16.8 Bell's palsy
16.8 Cerebral artery embolism
16.8 Ophthalmic migraine
16.8 Superior sagittal sinus thrombosis
16.8 Metastases to central nervous system
16.8 Ageusia
16.7 Electric shock sensation
16.4 Retinal migraine
16.0 Carotid artery dissection
16.0 Posterior reversible encephalopathy syndrome
15.3 Cerebral mass effect
15.3 Vaccination site paraesthesia
14.5 Haemorrhagic transformation stroke
14.2 Ischaemic stroke
13.7 Anaesthesia oral
13.0 Myasthenia gravis crisis
12.5 Cerebral venous thrombosis
12.2 Status migrainosus
11.5 Hepatic encephalopathy
11.5 Vascular dementia
11.4 Haemorrhagic stroke
10.7 Amaurosis fugax
10.7 Hypertensive encephalopathy
10.4 Intraventricular haemorrhage
10.4 Near death experience
10.3 Toxic encephalopathy
10.2 Carotid artery stenosis
10.1 Cerebellar infarction
10.1 Disorganised speech
10.1 Bradykinesia
10.0 Pharyngeal paraesthesia
9.9 Neurologic neglect syndrome
9.6 Parosmia
9.5 Vertebral artery occlusion
9.4 Autoscopy
9.2 Brain hypoxia
9.2 Paraesthesia ear
9.2 Embolic cerebral infarction
9.2 Cerebral microangiopathy
9.2 Lacunar stroke
8.8 Mental fatigue
8.4 Sciatic nerve injury
8.4 Loss of bladder sensation
8.4 Visual snow syndrome
8.1 Sleep deficit
7.6 Septic encephalopathy
7.4 Brain stem stroke
7.4 Basal ganglia stroke
7.3 Hemiplegic migraine
7.1 Orthostatic hypertension
7.1 Cold-stimulus headache
6.9 Brain compression
6.9 Cavernous sinus thrombosis
6.9 Upper motor neurone lesion
6.9 Vocal cord paresis
6.9 Spinal cord infarction
6.9 Ischaemic cerebral infarction
6.9 Spinal cord neoplasm
6.9 Exertional headache
6.9 Neuromuscular pain
6.9 Decreased nasolabial fold
6.9 Intensive care unit acquired weakness
6.9 Non-24-hour sleep-wake disorder
6.9 Subacute inflammatory demyelinating polyneuropathy
6.5 Cerebral arteriosclerosis
6.4 Dizziness exertional
6.4 Basal ganglia infarction
6.4 Visual brightness
6.2 Cluster headache
6.1 Head discomfort
6.1 Basilar artery occlusion
6.1 Dementia with Lewy bodies
6.0 Transient ischaemic attack
6.0 Dementia Alzheimer's type
6.0 Cerebrovascular accident
5.9 Carotid artery occlusion
5.9 Tinnitus
5.6 Intracranial mass
5.5 Subarachnoid haemorrhage
5.3 Cerebrospinal fluid leakage
5.3 Thunderclap headache
5.3 Hypogeusia
5.2 Phantom limb syndrome
5.0 Vertigo positional
5.0 Hypoaesthesia teeth
4.8 Cerebral infarction
4.8 Spinal stenosis
4.7 Hypoaesthesia eye
4.6 Metamorphopsia
4.6 Cerebral atrophy
4.6 Basilar artery thrombosis
4.4 Hemianaesthesia
4.4 Burning mouth syndrome
4.4 Injection site muscle weakness
4.3 Tension headache
4.3 Pharyngeal hypoaesthesia
4.2 Intracranial aneurysm
4.2 Creutzfeldt-Jakob disease
4.2 On and off phenomenon
4.1 Parkinson's disease
4.1 Hyposmia
4.1 Sciatica
4.0 Spinal cord compression
4.0 Vasogenic cerebral oedema
3.9 Subdural haemorrhage
3.9 New daily persistent headache
3.9 Motion sickness
3.8 Sensory overload
3.8 Burning feet syndrome
3.8 Band sensation
3.8 Resting tremor
3.8 Typical aura without headache
3.6 Paraesthesia oral
3.6 Cerebral haemorrhage
3.6 Facial spasm
3.6 IVth nerve paralysis
3.5 Brain herniation
3.5 Transient global amnesia
3.5 Vertebral foraminal stenosis
3.5 Vibratory sense increased
3.4 Cerebellar haemorrhage
3.4 Cerebral haematoma
3.4 Hypoaesthesia oral
3.4 Sedation
3.4 Meningioma
3.3 Vestibular neuronitis
3.3 Migraine
3.3 Hyperintensity in brain deep nuclei
3.3 Central vision loss
3.2 White matter lesion
3.2 Slow speech
3.1 Vertigo
3.1 Dysgeusia
3.1 Meniere's disease
3.1 Peripheral nerve injury
3.1 Post concussion syndrome
3.1 Hand-eye coordination impaired
3.0 Abnormal dreams
3.0 Cerebral disorder
3.0 Optic ischaemic neuropathy
2.9 Trigeminal nerve disorder
2.9 Cerebral calcification
2.9 Terminal insomnia
2.8 Tachyphrenia
2.8 Subdural haematoma
2.8 Deafness neurosensory
2.8 Small fibre neuropathy
2.8 Migraine with aura
2.8 Giant cell arteritis
2.7 Tongue movement disturbance
2.7 Dementia
2.7 Craniocerebral injury
2.7 Occipital neuralgia
2.7 Diabetic neuropathy
2.7 Hypertonic bladder
2.7 Diabetic foot
2.7 Fine motor skill dysfunction
2.6 Reduced facial expression
2.6 Restless legs syndrome
2.6 Multiple sclerosis relapse
2.6 Mastication disorder
2.6 Myasthenia gravis
2.6 Logorrhoea
2.5 Intranasal hypoaesthesia
2.5 Aphonia
2.5 Tunnel vision
2.5 Post viral fatigue syndrome
2.5 Photopsia
2.5 Nerve compression
2.5 Dizziness postural
2.4 Altered visual depth perception
2.4 Memory impairment
2.4 Sudden visual loss
2.4 Blepharospasm
2.4 Trigeminal neuralgia
2.3 Blindness unilateral
2.3 Psychogenic seizure
2.3 Temporomandibular joint syndrome
2.3 Spinal pain
2.2 Monoparesis
2.2 Facet joint syndrome
2.2 Hyperacusis
2.2 Facial nerve disorder
2.1 Dysstasia
2.1 Confusional state
2.1 Neurological symptom
2.1 Extraocular muscle paresis
2.1 Cervical spinal stenosis
2.1 Aura
2.1 Headache
2.0 Essential tremor
2.0 Hemiparesis
2.0 Vision blurred
2.0 Bradyphrenia
2.0 Disturbance in attention
2.0 Mental impairment
1.9 Balance disorder
1.9 Movement disorder
1.8 Dysarthria
1.8 Vestibular disorder
1.8 Allodynia
1.8 Lumbar spinal stenosis
1.8 Dizziness
1.8 Cervical radiculopathy
1.8 Sleep paralysis
1.7 Incontinence
1.7 Initial insomnia
1.7 Presyncope
1.7 Formication
1.7 Disorientation
1.6 Injection site hypoaesthesia
1.6 Hemiplegia
1.6 Haemorrhage intracranial
1.6 Burning sensation
1.6 Orthostatic hypotension
1.6 Aphasia
1.6 Hypoaesthesia
1.5 Blindness transient
1.5 Hypersomnia
1.5 Injection site paraesthesia
1.5 Unresponsive to stimuli
1.5 Skin burning sensation
1.5 Sensory disturbance
1.5 Sleep apnoea syndrome
1.4 Cognitive disorder
1.4 Sinus headache
1.4 Trismus
1.4 Photophobia
1.4 Blindness
1.4 Facial paresis
1.4 Neuralgia
1.4 Diplopia
1.3 Carpal tunnel syndrome
1.3 Incoherent
1.3 Paraesthesia
1.3 Amnesia
1.3 Motor dysfunction
1.3 Gait disturbance
1.2 Restlessness
1.2 Loss of consciousness
1.1 Mobility decreased

Metabolism and nutrition disorders

54.2 Acute respiratory failure
41.0 Hypervolaemia
18.3 Metabolic encephalopathy
14.5 Shock haemorrhagic
14.5 Eating disorder symptom
13.0 Anaemia macrocytic
12.0 Adult failure to thrive
11.5 Endocrine ophthalmopathy
11.1 Hypercapnia
10.7 Lactic acidosis
10.7 Food craving
9.5 Hypomagnesaemia
8.4 Hyperosmolar state
8.4 Salt craving
7.7 Spinal compression fracture
7.6 Diabetic nephropathy
5.0 Early satiety
4.6 Hypernatraemia
4.5 Goitre
4.5 Iron deficiency anaemia
4.4 Overweight
4.2 Dyslipidaemia
4.2 Type 2 diabetes mellitus
4.1 Diabetic ketoacidosis
4.1 Alcohol intolerance
4.1 Type V hyperlipidaemia
4.0 Fluid overload
4.0 Malnutrition
3.8 Hyperthyroidism
3.7 Abnormal loss of weight
3.7 Respiratory failure
3.6 Gout
3.5 Feeding disorder
3.5 Hunger
3.4 Adrenocortical insufficiency acute
3.4 Hyperkalaemia
3.4 Metabolic acidosis
3.2 Thirst decreased
3.1 Glucose tolerance impaired
2.9 Electrolyte imbalance
2.9 Chondrocalcinosis pyrophosphate
2.9 Hypophosphataemia
2.9 Hyperammonaemia
2.8 Small fibre neuropathy
2.8 Hyponatraemia
2.7 Diabetic neuropathy
2.7 Diabetic foot
2.6 Obesity
2.6 Iron deficiency
2.5 Insulin resistance
2.5 Hypovolaemia
2.4 Hepatic steatosis
2.4 Hypokalaemia
2.3 Hypoalbuminaemia
2.3 Osteopenia
2.2 Histamine intolerance
2.1 Vitamin D deficiency
2.1 Weight fluctuation
2.0 Thirst
1.9 Failure to thrive
1.9 Respiratory acidosis
1.9 Food refusal
1.9 Appetite disorder
1.8 Increased appetite
1.8 Vitamin B12 deficiency
1.7 Fluid retention
1.7 Hyperlipidaemia
1.5 Eating disorder
1.5 Hypothyroidism
1.3 Hypoglycaemia
1.2 Hypophagia
1.1 Dehydration

Psychiatric disorders

21.4 Premenstrual syndrome
16.0 Immunisation anxiety related reaction
14.5 Eating disorder symptom
12.0 Adult failure to thrive
11.5 Vascular dementia
10.7 Food craving
10.4 Near death experience
10.1 Disorganised speech
9.9 Fear of disease
9.9 Neurologic neglect syndrome
9.5 Behaviour disorder
9.4 Autoscopy
9.1 Impaired self-care
8.8 Mental fatigue
8.4 Exploding head syndrome
8.1 Hypervigilance
8.0 Time perception altered
6.9 Impaired reasoning
6.9 Non-24-hour sleep-wake disorder
6.5 Self-injurious ideation
6.1 Dementia with Lewy bodies
6.0 Dementia Alzheimer's type
5.7 Premenstrual dysphoric disorder
5.3 Negative thoughts
5.0 Fear of injection
4.8 Euphoric mood
4.3 Soliloquy
4.2 Creutzfeldt-Jakob disease
4.2 Feelings of worthlessness
4.2 Lack of spontaneous speech
4.2 Homicidal ideation
4.2 Helplessness
4.1 Acute psychosis
4.0 Panic attack
3.8 Alcohol abuse
3.8 Change in sustained attention
3.8 Derealisation
3.7 Fear of death
3.6 Laziness
3.6 Panic disorder
3.6 Mental status changes
3.5 Feeding disorder
3.5 Transient global amnesia
3.5 Mania
3.4 Feeling of despair
3.2 Slow speech
3.2 Generalised anxiety disorder
3.1 Dissociation
3.1 Suicidal ideation
3.1 Post concussion syndrome
3.1 Daydreaming
3.0 Abnormal dreams
2.9 Terminal insomnia
2.9 Depressed mood
2.8 Tachyphrenia
2.7 Schizophrenia
2.7 Dementia
2.7 Stress
2.7 Depressive symptom
2.7 Intrusive thoughts
2.7 Anxiety
2.6 Illusion
2.6 Reduced facial expression
2.6 Logorrhoea
2.5 Aphonia
2.5 Fear
2.4 Memory impairment
2.3 Psychogenic seizure
2.3 Nightmare
2.2 Alcohol poisoning
2.2 Major depression
2.2 Reading disorder
2.1 Confusional state
2.1 Sleep disorder
2.1 Paranoia
2.0 Frustration tolerance decreased
2.0 Bradyphrenia
2.0 Disturbance in attention
2.0 Mental impairment
1.9 Claustrophobia
1.9 Failure to thrive
1.9 Food refusal
1.9 Psychotic disorder
1.9 Choking sensation
1.9 Appetite disorder
1.8 Mental disorder
1.8 Dysarthria
1.8 Sleep paralysis
1.8 Erectile dysfunction
1.7 Delusion
1.7 Initial insomnia
1.7 Throat tightness
1.7 Nervousness
1.7 Formication
1.7 Disorientation
1.6 Apathy
1.6 Aphasia
1.6 Irritable bowel syndrome
1.5 Panic reaction
1.5 Hypersomnia
1.5 Hallucination, auditory
1.5 Eating disorder
1.5 Sleep apnoea syndrome
1.4 Cognitive disorder
1.4 Hallucination
1.4 Communication disorder
1.3 Hallucination, visual
1.3 Incoherent
1.3 Amnesia
1.2 Restlessness
1.2 Depression
1.2 Hypophagia

General disorders and administration site conditions

149.7 Vaccination site lymphadenopathy
80.2 Physical deconditioning
57.7 Disease recurrence
50.4 Vaccination site hypoaesthesia
44.6 Vaccination site pruritus
32.1 Premenstrual pain
24.2 Symptom recurrence
20.6 Facial discomfort
19.1 Vaccination site movement impairment
18.3 Critical illness
17.6 Mucosal hypertrophy
16.7 Electric shock sensation
15.3 Vaccination site paraesthesia
14.1 Vaccination site scar
14.1 Vaccination site joint pain
13.8 Vaccination site mass
13.7 Feeling of relaxation
13.7 Therapeutic product effect incomplete
13.2 Vaccination site urticaria
12.6 Fibrosis
12.0 Energy increased
12.0 Adult failure to thrive
11.5 Vaccination site erythema
11.5 Sensation of blood flow
11.5 Vaccination site hypersensitivity
10.6 Treatment noncompliance
10.2 Vaccination site haemorrhage
9.9 Vaccination site pain
9.2 Potentiating drug interaction
9.1 Impaired self-care
9.0 Vaccination site discomfort
8.4 Injection site thrombosis
8.1 Stenosis
7.6 Cardiac death
7.6 Vaccination site dryness
7.4 Hyperpyrexia
7.1 Febrile neutropenia
6.9 Extravasation
6.9 Visceral pain
6.9 Vaccination site discharge
6.9 Injection site muscle atrophy
6.9 Vaccination site rash
6.8 General physical health deterioration
6.7 Adverse food reaction
6.1 Mucosal ulceration
6.1 Catheter site haemorrhage
6.1 Vascular stent thrombosis
5.9 Vaccination site joint movement impairment
5.7 Cyst rupture
5.6 Vaccination site discolouration
5.5 Device related infection
5.4 Therapeutic product effect decreased
5.2 Phantom limb syndrome
5.0 Early satiety
4.4 Injection site muscle weakness
4.3 Incision site pain
4.2 Hypohidrosis
4.1 Exercise tolerance decreased
4.0 Inflammatory pain
4.0 Vaccination site reaction
3.8 Disease progression
3.8 Suprapubic pain
3.8 Ulcer haemorrhage
3.8 Vaccination site bruising
3.6 Procedural pain
3.6 Systemic inflammatory response syndrome
3.5 Vaccination site irritation
3.5 Vaccination site scab
3.5 Vaccination failure
3.5 Hunger
3.4 Multiple organ dysfunction syndrome
3.4 Vaccination site warmth
3.2 Sensitivity to weather change
3.2 Thirst decreased
3.2 Feeling abnormal
3.2 Hot flush
3.2 Sudden cardiac death
3.2 Feeling drunk
3.1 Vaccination site swelling
3.0 Fatigue
3.0 Chest discomfort
3.0 Axillary pain
2.9 Vaccination site vesicles
2.9 Injection site lymphadenopathy
2.9 Terminal state
2.8 Chest pain
2.8 Vaccination site induration
2.6 Still's disease
2.6 Endotracheal intubation complication
2.6 Injection site indentation
2.5 Temperature regulation disorder
2.5 Condition aggravated
2.5 Death
2.4 Organ failure
2.3 Bloody discharge
2.3 Night sweats
2.3 Feeling of body temperature change
2.3 Effusion
2.3 Deformity
2.3 Feeling jittery
2.3 Spinal pain
2.2 Polyp
2.2 Multi-organ disorder
2.2 Crepitations
2.2 Injection related reaction
2.1 Dysstasia
2.1 Chills
2.1 Sluggishness
2.1 Mucosal dryness
2.1 Sudden death
2.1 Vaccination site inflammation
2.1 Facial pain
2.0 Thirst
2.0 Sensation of foreign body
2.0 Flushing
2.0 Feeling cold
1.9 No recovery
1.9 Peripheral coldness
1.9 Balance disorder
1.9 Temperature intolerance
1.9 Flank pain
1.8 Ulcer
1.8 Increased appetite
1.7 Hyperhidrosis
1.7 Impaired healing
1.7 Secretion discharge
1.6 Injection site hypoaesthesia
1.6 Burning sensation
1.5 Cold sweat
1.5 Injection site paraesthesia
1.5 Adverse reaction
1.3 Swelling face
1.3 Inflammation
1.3 Adverse event
1.3 Asthenia
1.3 Gait disturbance
1.2 Peripheral swelling
1.2 Pain
1.1 Injection site pruritus
1.1 Mobility decreased
1.1 Malaise
1.1 Life threatening event

Musculoskeletal and connective tissue disorders

16.0 Lumbar vertebral fracture
14.5 Kyphosis
14.1 Vaccination site joint pain
13.0 Myasthenia gravis crisis
11.8 Bone swelling
11.5 Metastases to bone
10.3 Pelvic fracture
9.9 Fistula
9.9 Pelvic floor dysfunction
9.8 Femur fracture
7.7 Spinal compression fracture
7.6 Metastases to spine
7.6 Pelvic girdle pain
6.9 Neuromuscular pain
6.9 Decreased nasolabial fold
6.9 Intensive care unit acquired weakness
6.9 Injection site muscle atrophy
6.5 Vertebral lesion
6.4 Spinal deformity
6.2 Hip fracture
6.1 Radius fracture
6.0 Psoriatic arthropathy
6.0 Spondylitis
5.9 Vaccination site joint movement impairment
5.8 Plantar fasciitis
5.6 Vertebral osteophyte
5.4 Costochondritis
5.3 Intervertebral discitis
5.3 Bone lesion
5.1 Trigger finger
5.1 Muscle discomfort
5.0 Tenosynovitis stenosans
5.0 Polychondritis
5.0 Medial tibial stress syndrome
4.9 Rib fracture
4.9 Foot fracture
4.8 Ankle fracture
4.8 Spinal stenosis
4.7 Meniscus injury
4.6 Thoracic vertebral fracture
4.6 Chondrocalcinosis
4.6 Chest wall mass
4.5 Humerus fracture
4.4 Injection site muscle weakness
4.3 Spinal fracture
4.3 Upper limb fracture
4.1 Sciatica
3.9 Lower limb fracture
3.8 Burning feet syndrome
3.7 Dupuytren's contracture
3.6 Gout
3.5 Vertebral foraminal stenosis
3.3 Jaw disorder
3.3 Intervertebral disc space narrowing
3.2 Tibia fracture
3.1 Axillary mass
3.1 Spinal osteoarthritis
3.0 Ankylosing spondylitis
2.9 Chondrocalcinosis pyrophosphate
2.9 Coccydynia
2.9 Neck mass
2.7 Hand fracture
2.7 Compression fracture
2.7 Bone erosion
2.6 Restless legs syndrome
2.6 Back disorder
2.6 Still's disease
2.6 Mastication disorder
2.6 Muscle fatigue
2.6 Limb discomfort
2.6 Myasthenia gravis
2.5 Scoliosis
2.5 Hand deformity
2.4 Musculoskeletal chest pain
2.4 Rhabdomyolysis
2.3 Facial asymmetry
2.3 Osteopenia
2.3 Synovial cyst
2.3 Tendon discomfort
2.3 Temporomandibular joint syndrome
2.3 Spinal pain
2.2 Facet joint syndrome
2.2 Foot deformity
2.2 Ligament sprain
2.2 Diaphragmalgia
2.1 Dysstasia
2.1 Joint injury
2.1 Joint instability
2.1 Chills
2.1 Ligament rupture
2.1 Cervical spinal stenosis
2.1 Muscle tightness
2.1 Musculoskeletal discomfort
2.1 Bone contusion
2.1 Tendon pain
2.0 Pain in jaw
2.0 Facial bones fracture
2.0 Spondylolisthesis
2.0 Spinal disorder
2.0 Muscle strain
2.0 Ligament pain
2.0 Bone pain
1.9 Lipoma
1.9 Intervertebral disc degeneration
1.9 Butterfly rash
1.9 Flank pain
1.8 Intervertebral disc protrusion
1.8 Groin pain
1.8 Muscle rupture
1.8 Epicondylitis
1.8 Lumbar spinal stenosis
1.8 Muscle spasms
1.8 Joint dislocation
1.7 Joint contracture
1.7 Intervertebral disc disorder
1.7 Sjogren's syndrome
1.7 Arthritis reactive
1.7 Exostosis
1.7 Arthralgia
1.6 Joint lock
1.6 Muscle contracture
1.6 Rheumatoid arthritis
1.5 Back pain
1.5 Polymyalgia rheumatica
1.4 Trismus
1.4 Pain in extremity
1.4 Myalgia
1.4 Joint swelling
1.3 Motor dysfunction
1.3 Gait disturbance
1.1 Neck pain
1.1 Mobility decreased

Respiratory, thoracic and mediastinal disorders

68.2 Lung opacity
55.0 Agonal respiration
54.2 Acute respiratory failure
35.6 Anosmia
26.6 Pulmonary thrombosis
25.2 Dyspnoea paroxysmal nocturnal
24.4 Pleural thickening
21.6 Pulmonary embolism
21.4 Pulmonary calcification
21.4 Pulmonary artery dilatation
18.6 Pulmonary infarction
18.3 Sinonasal obstruction
17.6 Pulmonary arterial hypertension
17.2 Acute pulmonary oedema
17.2 Pulmonary granuloma
14.4 Pulmonary mass
14.1 Dyspnoea at rest
13.7 Hilar lymphadenopathy
13.5 Acquired diaphragmatic eventration
13.4 Lymphadenopathy mediastinal
13.0 Lung cancer metastatic
13.0 Pneumonia bacterial
12.6 Lung infiltration
12.4 Lung consolidation
12.2 Tonsillolith
11.6 Paranasal sinus discomfort
11.5 Dyspnoea exertional
11.5 Oropharyngeal discomfort
11.1 Lung hyperinflation
11.1 Hypercapnia
10.7 Bronchial secretion retention
10.0 Pharyngeal paraesthesia
9.6 Parosmia
9.3 Pharyngeal swelling
9.2 Throat clearing
9.2 Brain hypoxia
9.2 Traumatic lung injury
9.0 Paranasal sinus inflammation
9.0 Pulmonary pain
7.6 Haemothorax
7.6 Idiopathic pulmonary fibrosis
7.6 Small cell lung cancer
7.5 Chronic obstructive pulmonary disease
7.0 Sinus pain
6.9 Pulmonary fibrosis
6.9 Pneumonia legionella
6.9 Vocal cord paresis
6.6 Pulmonary vascular disorder
6.5 Pulmonary hypertension
6.5 Interstitial lung disease
6.3 Lower respiratory tract congestion
6.1 Hiatus hernia
6.1 Lung abscess
6.1 Paranasal sinus hyposecretion
6.1 Pneumonia viral
6.0 Orthopnoea
5.7 Chronic respiratory disease
5.7 Severe acute respiratory syndrome
5.6 Nasal dryness
5.3 Pleural fibrosis
5.3 Paranasal cyst
5.3 Infectious pleural effusion
4.9 Nasal pruritus
4.7 Pleural effusion
4.6 Allergic sinusitis
4.6 Pneumomediastinum
4.6 Vocal cord inflammation
4.6 Diaphragmatic spasm
4.6 Acute respiratory distress syndrome
4.4 Diaphragmatic disorder
4.4 Emphysema
4.3 Pneumocystis jirovecii pneumonia
4.3 Pharyngeal hypoaesthesia
4.2 Nasal herpes
4.1 Organising pneumonia
4.1 Hyposmia
4.1 Lung adenocarcinoma
4.1 Mediastinal mass
4.1 Pharyngeal mass
4.0 Atelectasis
4.0 Respiratory tract irritation
4.0 Pleuritic pain
3.9 Increased viscosity of upper respiratory secretion
3.8 Suffocation feeling
3.8 Nasal mucosal blistering
3.8 Pharyngeal haemorrhage
3.8 Pneumothorax spontaneous
3.8 Alveolar lung disease
3.8 Sputum discoloured
3.7 Atypical pneumonia
3.7 Bronchial wall thickening
3.7 Pneumonia staphylococcal
3.7 Hypoxia
3.7 Respiratory failure
3.6 Sinus disorder
3.5 Pneumonia aspiration
3.5 Lung neoplasm malignant
3.4 Cor pulmonale
3.4 Tachypnoea
3.4 Pneumothorax
3.3 Pneumonitis
3.2 Cardio-respiratory arrest
3.2 Vocal cord dysfunction
3.1 Coronavirus infection
3.1 Painful respiration
3.1 Upper-airway cough syndrome
3.1 Bronchial irritation
3.1 Reflux laryngitis
3.0 Irregular breathing
3.0 Chest discomfort
2.9 Productive cough
2.9 Nasal disorder
2.9 Sputum purulent
2.9 Tonsillar erythema
2.8 Respiratory tract congestion
2.8 Chest pain
2.8 Haemoptysis
2.8 Dry throat
2.6 Endotracheal intubation complication
2.5 Sputum increased
2.5 Intranasal hypoaesthesia
2.5 Nasal discomfort
2.5 Aphonia
2.5 Bronchiectasis
2.4 Musculoskeletal chest pain
2.4 Pleurisy
2.4 Seasonal allergy
2.4 Sinus congestion
2.4 Throat irritation
2.3 Pulmonary oedema
2.3 Rhonchi
2.3 Pulmonary congestion
2.3 Oropharyngeal pain
2.2 Nasopharyngitis
2.2 Nasal injury
2.2 Diaphragmalgia
2.2 Epistaxis
2.1 Aspiration
2.1 Lower respiratory tract infection
2.1 Dyspnoea
2.0 Hypopnoea
2.0 Rales
1.9 Respiratory acidosis
1.9 Nasal inflammation
1.9 Choking sensation
1.8 Nasal congestion
1.8 Rhinalgia
1.8 Chronic sinusitis
1.8 Vocal cord disorder
1.8 Tonsillar hypertrophy
1.8 Tonsillar disorder
1.7 Cough
1.7 Throat tightness
1.7 Obstructive airways disorder
1.7 Respiration abnormal
1.7 Sneezing
1.7 Hiccups
1.6 Yawning
1.6 Acute sinusitis
1.6 Rhinorrhoea
1.5 Sleep apnoea syndrome
1.4 Sinus headache
1.3 Pneumonia
1.3 Respiratory distress
1.2 Sinusitis

Renal and urinary disorders

24.4 Lower urinary tract symptoms
22.1 Urinary tract discomfort
21.4 Ureterolithiasis
20.2 Renal infarct
17.6 Renal atrophy
17.6 Bladder hypertrophy
16.0 Bladder dilatation
15.3 End stage renal disease
15.2 Chronic kidney disease
12.2 Urinary tract obstruction
11.5 Renal haemorrhage
11.4 Acute kidney injury
10.7 Bacteriuria
9.9 Asymptomatic bacteriuria
9.2 Bladder cancer
9.2 Genitourinary symptom
8.4 Haemorrhage urinary tract
8.4 Loss of bladder sensation
7.6 Bladder discomfort
7.6 Diabetic nephropathy
7.6 Cystitis noninfective
7.3 Renal cyst
6.9 Bladder irritation
6.9 Renal cancer
6.9 Urethral haemorrhage
6.9 Prerenal failure
5.9 IgA nephropathy
5.5 Renal mass
5.2 Bladder spasm
5.0 Urinary tract inflammation
4.9 Nephropathy
4.8 Nephrolithiasis
3.8 Hydronephrosis
3.8 Urinary tract infection bacterial
3.7 Bladder pain
3.6 Pelvic discomfort
3.6 Renal pain
3.6 Calculus urinary
3.5 Urosepsis
3.4 Glomerulonephritis rapidly progressive
3.4 Renal impairment
3.3 Polyuria
3.2 Glomerulonephritis membranous
3.2 Urine flow decreased
3.1 Renal tubular necrosis
3.1 Renal injury
3.1 Urinary tract pain
2.9 Urethral pain
2.7 Azotaemia
2.7 Hypertonic bladder
2.6 Urine odour abnormal
2.6 Bladder disorder
2.5 Kidney infection
2.3 Cystitis
2.3 Micturition urgency
2.2 Pyuria
2.2 Pelvic pain
2.1 Renal disorder
2.1 Urinary tract infection
2.1 Renal failure
2.1 Chromaturia
2.0 Urine abnormality
2.0 Cystitis interstitial
1.9 Flank pain
1.7 Incontinence
1.7 Fluid retention
1.7 Arthritis reactive
1.7 Pollakiuria
1.6 Dysuria
1.5 Haematuria
1.3 Urinary retention

Reproductive system and breast disorders

115.5 Postmenopausal haemorrhage
32.1 Premenstrual pain
29.9 Polymenorrhoea
27.5 Suppressed lactation
24.9 Oligomenorrhoea
21.4 Ovulation disorder
21.4 Premenstrual syndrome
17.7 Heavy menstrual bleeding
16.4 Endometrial thickening
15.3 Galactostasis
15.0 Intermenstrual bleeding
14.4 Uterine spasm
13.6 Dysmenorrhoea
13.4 Menstrual disorder
13.0 Intra-abdominal fluid collection
12.7 Breast cyst
12.2 Breast cancer metastatic
12.2 Menstrual discomfort
11.6 Menstruation irregular
11.1 Abnormal uterine bleeding
10.7 Varicocele
10.4 Breast mass
10.0 Hypomenorrhoea
9.9 Breast cellulitis
9.5 Nipple swelling
9.5 Breast discomfort
9.2 Breast inflammation
9.2 Invasive ductal breast carcinoma
9.2 Genitourinary symptom
9.2 Triple negative breast cancer
9.0 Menstruation delayed
8.4 Bartholin's cyst
8.4 Menometrorrhagia
7.7 Breast discharge
7.6 Testis discomfort
7.6 Uterine leiomyoma
6.9 Breast tenderness
6.9 Adnexa uteri mass
6.9 Uterine pain
6.8 Uterine haemorrhage
6.6 Adnexa uteri pain
6.5 Nipple disorder
6.5 Uterine cancer
6.1 Prostatitis
6.1 Uterine inflammation
6.1 Breast swelling
5.7 Nipple pain
5.7 Premenstrual dysphoric disorder
5.5 Genital ulceration
5.2 Vaginal haemorrhage
5.1 Menopausal symptoms
5.0 Benign prostatic hyperplasia
5.0 Hydrocele
5.0 Pelvic fluid collection
4.7 Breast enlargement
4.7 Prostatomegaly
4.6 Fibrocystic breast disease
4.5 Testicular pain
4.2 Anovulatory cycle
4.2 Fibroadenoma of breast
4.1 Breast oedema
3.9 Breast pain
3.9 Breast cancer female
3.8 Haemorrhagic ovarian cyst
3.8 Vulval ulceration
3.7 Lactation disorder
3.7 Vulvovaginal pain
3.6 Pelvic discomfort
3.6 Breast induration
3.6 Ovarian enlargement
3.4 Breast engorgement
3.3 Lichen sclerosus
3.3 Breast cancer
3.2 Vulvovaginal dryness
3.2 Hot flush
3.1 Prostate cancer
3.1 Vaginal odour
3.1 Vulvovaginal rash
3.0 Mastitis
3.0 Amenorrhoea
2.7 Vaginal ulceration
2.5 Vulvovaginal mycotic infection
2.5 Vulvovaginal discomfort
2.4 Haematospermia
2.4 Breast disorder female
2.4 Vaginal discharge
2.3 Ovarian cyst ruptured
2.3 Genital discomfort
2.2 Pelvic pain
2.1 Vulvovaginal burning sensation
2.0 Testicular swelling
1.9 Genital pain
1.8 Vulvovaginal swelling
1.8 Scrotal swelling
1.8 Erectile dysfunction
1.5 Genital herpes
1.5 Haematuria
1.5 Ovarian cyst

Investigations

104.6 Prohormone brain natriuretic peptide increased
48.3 Angiogram pulmonary abnormal
35.9 Troponin abnormal
30.8 Cardiac imaging procedure abnormal
30.0 Arteriogram carotid abnormal
23.9 Angiogram cerebral abnormal
23.3 Electrocardiogram ST-T segment abnormal
22.9 Ventilation/perfusion scan abnormal
20.0 Ultrasound foetal abnormal
18.8 Fibrin D dimer increased
17.6 Arteriogram coronary abnormal
17.6 Walking distance test abnormal
16.8 Ultrasound breast abnormal
16.6 N-terminal prohormone brain natriuretic peptide increased
15.8 Venogram abnormal
15.8 Computerised tomogram thorax abnormal
15.2 Ultrasound Doppler abnormal
14.5 Anticoagulation drug level above therapeutic
14.3 Cardiac telemetry abnormal
14.1 Computerised tomogram pelvis abnormal
13.7 Thyroid hormones increased
13.7 Heparin-induced thrombocytopenia test positive
13.7 Anti-thyroid antibody increased
13.3 Brain natriuretic peptide increased
13.0 Immature granulocyte count increased
13.0 Wall motion score index abnormal
12.8 Procalcitonin increased
12.8 Blood pH increased
12.3 Cardiac monitoring abnormal
12.2 Enzyme level increased
12.2 Magnetic resonance imaging breast abnormal
11.8 Body temperature abnormal
11.8 Mammogram abnormal
11.7 Blood creatine increased
11.6 Biopsy breast abnormal
11.6 Creatinine renal clearance decreased
11.5 Angiogram peripheral abnormal
11.5 Thyroid gland scan abnormal
11.5 Inflammatory marker decreased
11.2 Thyroxine free increased
11.1 Electrocardiogram ST segment abnormal
10.8 Troponin increased
10.7 Breath sounds absent
10.5 Glomerular filtration rate decreased
10.1 Klebsiella test positive
9.9 Blood urea abnormal
9.9 Electrocardiogram QRS complex prolonged
9.9 International normalised ratio abnormal
9.9 Right ventricular systolic pressure increased
9.7 Catheterisation cardiac abnormal
9.7 Vital functions abnormal
9.5 Tri-iodothyronine decreased
9.5 Pulmonary imaging procedure abnormal
9.2 Blood lactic acid abnormal
9.2 Urinary occult blood positive
9.2 Brain natriuretic peptide decreased
9.2 NIH stroke scale abnormal
9.2 Ultrasound ovary abnormal
9.0 Oesophagogastroduodenoscopy abnormal
8.9 Cardiac stress test abnormal
8.8 Imaging procedure abnormal
8.4 Anticoagulation drug level below therapeutic
8.4 Liver function test decreased
8.4 Magnetic resonance imaging abdominal abnormal
8.2 Serum ferritin increased
8.1 Scan with contrast abnormal
7.8 Ultrasound scan vagina abnormal
7.8 Electrocardiogram PR segment depression
7.6 Albumin globulin ratio decreased
7.6 Oestradiol increased
7.6 Pseudomonas test positive
7.6 Stress echocardiogram abnormal
7.6 Thyroid hormones decreased
7.6 Ejection fraction decreased
7.5 Computerised tomogram abdomen abnormal
7.4 Computerised tomogram head abnormal
7.4 Mean cell haemoglobin concentration decreased
7.1 Total lung capacity decreased
7.0 PO2 decreased
6.9 Retinal function test abnormal
6.9 Biopsy prostate abnormal
6.9 Foetal non-stress test abnormal
6.8 Angiogram abnormal
6.4 Oxygen consumption decreased
6.3 Blood osmolarity decreased
6.3 Tri-iodothyronine increased
6.2 Heart rate abnormal
6.1 Blood magnesium abnormal
6.1 Carcinoembryonic antigen increased
6.1 Lipids abnormal
6.1 Carbohydrate antigen 125 increased
6.1 Synovial fluid crystal present
6.1 Biopsy pancreas abnormal
6.1 Vitamin B12 decreased
6.0 Blood fibrinogen increased
5.9 Cystoscopy abnormal
5.9 Electrocardiogram ST segment depression
5.8 Blood magnesium decreased
5.8 Electrocardiogram repolarisation abnormality
5.8 Ultrasound thyroid abnormal
5.7 Blood oestrogen increased
5.7 HIV test false positive
5.7 Electrocardiogram PR prolongation
5.7 Echocardiogram abnormal
5.6 Left ventricular end-diastolic pressure increased
5.6 Ultrasound kidney abnormal
5.6 Chest X-ray abnormal
5.3 Ultrasound uterus abnormal
5.3 Fluorescence angiogram abnormal
5.3 Cytokine increased
5.3 Blood creatinine abnormal
5.1 Blood pressure diastolic increased
5.1 Liver function test increased
5.0 Troponin T increased
5.0 Blood bicarbonate increased
5.0 Blood osmolarity increased
5.0 Venous oxygen saturation decreased
4.9 PCO2 decreased
4.9 Electrocardiogram ambulatory abnormal
4.8 Acoustic stimulation tests abnormal
4.8 Glomerular filtration rate increased
4.8 Blood lactic acid decreased
4.7 Blood pressure abnormal
4.7 Prothrombin time shortened
4.6 Electrocardiogram QRS complex abnormal
4.6 Heart sounds abnormal
4.6 Oxygen saturation abnormal
4.6 Mean platelet volume increased
4.6 Ear, nose and throat examination abnormal
4.6 General physical condition abnormal
4.6 Pancreatic enzymes increased
4.6 Interleukin level increased
4.5 Sputum culture positive
4.5 Inflammatory marker increased
4.4 Coma scale abnormal
4.4 Muscle strength abnormal
4.4 Blood gases abnormal
4.3 Electrocardiogram T wave inversion
4.3 Blood oestrogen decreased
4.3 Blood creatinine increased
4.3 Activated partial thromboplastin time shortened
4.3 Electrocardiogram T wave abnormal
4.3 Oxygen saturation decreased
4.2 Glycosylated haemoglobin increased
4.2 QRS axis abnormal
4.2 Electrocardiogram ST segment elevation
4.2 Carbon dioxide increased
4.2 Blood testosterone increased
4.2 Sigmoidoscopy abnormal
4.2 Ultrasound eye abnormal
4.2 Cardiac function test abnormal
4.2 Thyroid stimulating immunoglobulin increased
4.2 Heart rate irregular
4.1 Eosinophil percentage decreased
4.1 International normalised ratio increased
4.1 Blood calcium decreased
4.1 International normalised ratio decreased
4.0 C-reactive protein abnormal
4.0 Metabolic function test abnormal
4.0 Oxygen saturation increased
4.0 Blood chloride decreased
4.0 Immature granulocyte percentage increased
3.9 Mean cell volume increased
3.8 Bilirubin urine present
3.8 Blood luteinising hormone decreased
3.8 Lipase decreased
3.8 Blood bilirubin abnormal
3.8 Positron emission tomogram abnormal
3.8 Red cell distribution width increased
3.8 Eosinophil count decreased
3.7 Blood iron decreased
3.7 Blood thyroid stimulating hormone increased
3.7 Electrocardiogram abnormal
3.7 PCO2 increased
3.7 Blood lactic acid increased
3.7 Blood chloride increased
3.7 Blood test abnormal
3.6 Transferrin saturation decreased
3.6 Blood glucose fluctuation
3.6 X-ray dental abnormal
3.6 Mean cell haemoglobin increased
3.6 Ultrasound pelvis abnormal
3.5 Histamine level increased
3.5 Scan abnormal
3.5 Vitamin D decreased
3.4 Biopsy colon abnormal
3.4 Blood parathyroid hormone increased
3.4 Blood sodium decreased
3.4 Urine leukocyte esterase positive
3.3 Haemoglobin abnormal
3.3 Bone density abnormal
3.3 Faecal calprotectin increased
3.3 Globulins increased
3.3 Renal function test abnormal
3.3 Blood sodium increased
3.3 Blood pH decreased
3.2 Inspiratory capacity decreased
3.2 Haemoglobin decreased
3.2 Blood glucose abnormal
3.2 Swallow study abnormal
3.2 C-reactive protein decreased
3.2 Coagulation test abnormal
3.1 Blood thyroid stimulating hormone decreased
3.1 Basophil count decreased
3.1 Blood bilirubin decreased
3.1 Activated partial thromboplastin time prolonged
3.1 Blood magnesium increased
3.1 Blood pressure systolic increased
3.1 Cardiolipin antibody positive
3.1 Electrocardiogram T wave peaked
3.1 Full blood count decreased
3.1 Glycosylated haemoglobin decreased
3.1 Blood urea nitrogen/creatinine ratio increased
3.1 Base excess increased
3.1 Coombs test positive
3.1 Helicobacter test positive
3.1 Rhesus antigen positive
3.0 Escherichia test positive
3.0 Low density lipoprotein increased
3.0 Serum ferritin decreased
3.0 Electrocardiogram ST-T change
3.0 Basophil percentage decreased
3.0 Ultrasound liver abnormal
3.0 Prostatic specific antigen increased
2.9 Haptoglobin decreased
2.9 Blood potassium decreased
2.9 PO2 increased
2.9 Blood urine present
2.9 Colonoscopy abnormal
2.9 Blood albumin decreased
2.9 Anion gap decreased
2.9 Crystal urine present
2.8 Blood urea increased
2.8 Transaminases increased
2.8 Bronchoscopy abnormal
2.8 Human chorionic gonadotropin decreased
2.8 Electrocardiogram QT prolonged
2.8 Monocyte count decreased
2.8 Blood phosphorus decreased
2.7 Thyroid function test abnormal
2.7 Progesterone decreased
2.7 Computerised tomogram kidney abnormal
2.7 Blood pressure increased
2.7 Heart rate increased
2.7 Lipase increased
2.7 Urinary sediment present
2.7 Blood cholesterol decreased
2.7 Biopsy liver abnormal
2.7 Prothrombin time prolonged
2.6 Hormone level abnormal
2.6 Computerised tomogram abnormal
2.6 Specific gravity urine increased
2.6 Blood bicarbonate decreased
2.6 Red blood cell count decreased
2.6 Aspartate aminotransferase decreased
2.6 Human chorionic gonadotropin abnormal
2.6 Thyroxine free decreased
2.6 Protein total decreased
2.6 Vitamin B12 increased
2.6 Audiogram abnormal
2.5 Sputum abnormal
2.5 X-ray of pelvis and hip abnormal
2.5 Antiacetylcholine receptor antibody positive
2.5 Blood potassium increased
2.4 Enterococcus test positive
2.4 High density lipoprotein increased
2.4 Haemoglobin increased
2.3 Pulse absent
2.3 Pulmonary function test abnormal
2.3 Red blood cell count increased
2.3 Differential white blood cell count abnormal
2.3 Ophthalmological examination abnormal
2.3 Antinuclear antibody increased
2.3 Blood thyroid stimulating hormone abnormal
2.3 Endoscopy upper gastrointestinal tract abnormal
2.2 White blood cell count abnormal
2.2 Culture urine positive
2.2 Haematocrit increased
2.2 C-reactive protein increased
2.2 Thyroxine decreased
2.1 Magnetic resonance imaging thoracic abnormal
2.1 Magnetic resonance imaging head abnormal
2.1 Lymphocyte count decreased
2.1 Blood pressure systolic decreased
2.0 Blood glucose increased
2.0 Hepatic enzyme increased
2.0 Carbon dioxide decreased
2.0 Blood fibrinogen decreased
2.0 Pulse abnormal
2.0 Nitrite urine absent
2.0 Myocardial necrosis marker increased
2.0 Blood creatine phosphokinase decreased
2.0 Full blood count abnormal
1.9 Ammonia increased
1.9 Foetal heart rate abnormal
1.9 Blood urea decreased
1.9 Pupillary light reflex tests abnormal
1.9 Mean cell haemoglobin decreased
1.9 Heart rate decreased
1.8 Haematocrit decreased
1.8 Endoscopy abnormal
1.8 High density lipoprotein decreased
1.8 Blood triglycerides increased
1.8 Red blood cells urine positive
1.8 Blood glucose decreased
1.8 White blood cells urine positive
1.8 Urine ketone body absent
1.7 Lymphocyte percentage decreased
1.7 Glucose urine absent
1.7 Blood cholesterol increased
1.7 Brain scan abnormal
1.7 Weight increased
1.6 Ultrasound antenatal screen abnormal
1.6 Blood urine absent
1.6 Blood uric acid increased
1.6 Blood bilirubin increased
1.6 Bilirubin conjugated increased
1.5 Biopsy bone marrow abnormal
1.5 Gram stain positive
1.5 Staphylococcus test positive
1.5 Platelet count decreased
1.5 Ultrasound scan abnormal
1.5 Troponin I increased
1.5 Blood culture positive
1.5 Protein urine absent
1.4 Monocyte percentage increased
1.4 Rheumatoid factor increased
1.4 White blood cell count decreased
1.4 Protein total increased
1.4 Spinal X-ray abnormal
1.4 Neutrophil percentage increased
1.4 Urine analysis abnormal
1.3 Breath sounds abnormal
1.3 Weight decreased
1.3 Neutrophil count increased
1.2 Blood alkaline phosphatase increased
1.2 Blood pressure decreased
1.2 Antinuclear antibody positive

Vascular disorders

115.5 Postmenopausal haemorrhage
87.8 Blood loss anaemia
60.3 Cerebellar stroke
56.5 Aortic stenosis
50.7 Cerebral venous sinus thrombosis
49.3 Superficial vein thrombosis
45.8 Jugular vein thrombosis
38.9 Aortic dissection
38.9 Peripheral artery occlusion
38.6 Cerebral artery occlusion
38.2 Portal vein thrombosis
38.2 Cardiovascular symptom
34.2 Thrombophlebitis superficial
34.0 Embolic stroke
33.6 Carotid artery thrombosis
33.6 Embolism venous
33.2 Hypertensive urgency
32.3 Aortic arteriosclerosis
29.4 Internal haemorrhage
28.1 Cerebral thrombosis
26.7 Peripheral embolism
26.6 Pulmonary thrombosis
25.2 Aortic thrombosis
24.4 Chillblains
24.4 Lacunar infarction
24.1 Aortic dilatation
23.7 Brain stem infarction
23.7 Cerebral artery stenosis
23.3 Hypertensive emergency
22.9 Mesenteric vein thrombosis
22.9 Cerebral small vessel ischaemic disease
22.1 Cerebral artery thrombosis
21.8 Intracardiac thrombus
21.6 Pulmonary embolism
20.6 Blue toe syndrome
20.6 Thalamic infarction
20.2 Renal infarct
20.0 Multisystem inflammatory syndrome in children
19.1 Basal ganglia haemorrhage
18.6 Pulmonary infarction
17.9 Arteriosclerosis coronary artery
17.8 Acute myocardial infarction
17.6 Embolism arterial
17.6 Venous thrombosis limb
17.6 Pulmonary arterial hypertension
17.6 Multisystem inflammatory syndrome
17.1 Retinal artery occlusion
16.8 Cerebral artery embolism
16.8 Superior sagittal sinus thrombosis
16.4 Pelvic venous thrombosis
16.4 Peripheral ischaemia
16.4 Retinal migraine
16.0 Carotid artery dissection
16.0 Vascular calcification
16.0 Peripheral artery thrombosis
16.0 Deep vein thrombosis
15.7 Peripheral arterial occlusive disease
15.4 Retinal vein occlusion
15.3 Portal hypertension
15.3 Splenic vein thrombosis
15.3 Vena cava thrombosis
14.5 Shock haemorrhagic
14.5 Haemorrhagic transformation stroke
14.2 Ischaemic stroke
14.0 Coronary artery dissection
13.7 Haemoperitoneum
13.7 Hepatic vein thrombosis
13.7 Venous occlusion
13.5 Acute coronary syndrome
13.2 Splenic infarction
13.0 Urticarial vasculitis
12.5 Cerebral venous thrombosis
12.4 Thrombosis
12.2 Coronary artery thrombosis
12.2 Status migrainosus
12.2 Haemorrhoidal haemorrhage
12.1 Essential hypertension
12.1 Arterial occlusive disease
11.8 Hypertensive heart disease
11.5 Ischaemic hepatitis
11.5 Renal haemorrhage
11.5 Vitreous haemorrhage
11.5 Vascular dementia
11.4 Haemorrhagic stroke
11.1 Cardiogenic shock
11.1 Coronary artery stenosis
10.7 Amaurosis fugax
10.7 Hypertensive encephalopathy
10.7 Varicocele
10.7 Intestinal haemorrhage
10.4 Intraventricular haemorrhage
10.2 Vaccination site haemorrhage
10.2 Carotid artery stenosis
10.1 Cerebellar infarction
9.9 Coronary artery occlusion
9.9 Eyelid contusion
9.6 Colitis ischaemic
9.5 Vertebral artery occlusion
9.2 Brain hypoxia
9.2 Embolic cerebral infarction
9.2 Cerebral microangiopathy
9.2 Lacunar stroke
8.8 Stress cardiomyopathy
8.4 Gastric haemorrhage
8.4 Injection site thrombosis
8.4 Haemorrhage urinary tract
8.4 Procedural haemorrhage
8.3 Embolism
8.1 Aortic aneurysm
7.6 Arterial thrombosis
7.6 Haemothorax
7.6 Septic shock
7.6 Retroperitoneal haematoma
7.4 Upper gastrointestinal haemorrhage
7.4 Brain stem stroke
7.4 Basal ganglia stroke
7.3 Angina pectoris
7.3 Hemiplegic migraine
7.1 Orthostatic hypertension
6.9 Cavernous sinus thrombosis
6.9 Labile hypertension
6.9 Urethral haemorrhage
6.9 Spinal cord infarction
6.9 Ischaemic cerebral infarction
6.9 Prerenal failure
6.9 Vein collapse
6.9 Vein rupture
6.8 Uterine haemorrhage
6.6 Post procedural haemorrhage
6.6 Pulmonary vascular disorder
6.5 Pulmonary hypertension
6.5 Ocular vascular disorder
6.5 Varices oesophageal
6.5 Heparin-induced thrombocytopenia
6.5 Cerebral arteriosclerosis
6.4 Dizziness exertional
6.4 Subclavian vein thrombosis
6.4 Basal ganglia infarction
6.4 Hypovolaemic shock
6.1 Mesenteric artery thrombosis
6.1 Basilar artery occlusion
6.1 Catheter site haemorrhage
6.1 Varicophlebitis
6.1 Vascular stent thrombosis
6.1 Microvascular coronary artery disease
6.0 Transient ischaemic attack
6.0 Cerebrovascular accident
5.9 Carotid artery occlusion
5.9 Vein disorder
5.9 Superficial vein prominence
5.8 Angina unstable
5.7 Vascular rupture
5.7 Artery dissection
5.7 Gangrene
5.5 Subarachnoid haemorrhage
5.5 Ischaemia
5.3 Accelerated hypertension
5.3 Haemorrhagic disorder
5.3 Vascular pain
5.2 Venous thrombosis
5.2 Vaginal haemorrhage
5.1 Wound haemorrhage
5.1 Labile blood pressure
5.0 Haemodynamic instability
5.0 Varicose vein
5.0 Peripheral venous disease
5.0 Arterial stenosis
4.8 Cerebral infarction
4.8 Intestinal ischaemia
4.7 Capillary fragility
4.6 Axillary vein thrombosis
4.6 Basilar artery thrombosis
4.6 Chronic pigmented purpura
4.6 Myocardial infarction
4.6 Acute respiratory distress syndrome
4.4 Myocardial ischaemia
4.3 Conjunctival haemorrhage
4.2 Intracranial aneurysm
4.2 Erythromelalgia
4.2 Telangiectasia
4.0 Arterial disorder
4.0 Blood pressure fluctuation
4.0 Tongue haemorrhage
3.9 Subdural haemorrhage
3.9 Eye haemorrhage
3.9 Hypertensive crisis
3.8 Haemangioma of liver
3.8 Haemorrhagic ovarian cyst
3.8 Oral contusion
3.8 Pharyngeal haemorrhage
3.8 Large intestinal haemorrhage
3.8 Ulcer haemorrhage
3.8 Microangiopathy
3.8 Haemorrhagic diathesis
3.8 Vaccination site bruising
3.6 Cerebral haemorrhage
3.6 Systemic inflammatory response syndrome
3.6 Vein discolouration
3.5 Eye contusion
3.4 Cerebellar haemorrhage
3.4 Cor pulmonale
3.4 Cerebral haematoma
3.4 Intermittent claudication
3.3 Migraine
3.3 Poor peripheral circulation
3.3 Aneurysm
3.2 Phlebitis superficial
3.2 White matter lesion
3.2 Hot flush
3.2 Arteriosclerosis
3.1 Anal haemorrhage
3.0 Optic ischaemic neuropathy
2.9 Haemangioma of skin
2.9 Aneurysm ruptured
2.8 Haemoptysis
2.8 Subdural haematoma
2.8 Migraine with aura
2.8 Giant cell arteritis
2.7 Hypertension
2.7 Coronary artery disease
2.7 Antiphospholipid syndrome
2.7 Diabetic foot
2.6 Shock symptom
2.6 Thrombophlebitis
2.5 Arteriospasm coronary
2.5 Dizziness postural
2.4 Haematospermia
2.4 Disseminated intravascular coagulation
2.4 Infarction
2.4 Rectal haemorrhage
2.3 Bloody discharge
2.3 Pulmonary congestion
2.2 Epistaxis
2.1 Capillary disorder
2.1 Bone contusion
2.0 Gingival bleeding
2.0 Haemorrhage in pregnancy
2.0 Flushing
2.0 Ear haemorrhage
1.9 Peripheral coldness
1.9 Lymphoedema
1.9 Haemorrhoids
1.9 Raynaud's phenomenon
1.9 Thrombotic thrombocytopenic purpura
1.8 Dizziness
1.7 Presyncope
1.6 Hypotension
1.6 Haemorrhage intracranial
1.6 Orthostatic hypotension
1.6 Gastrointestinal haemorrhage
1.5 Haematuria
1.5 Skin haemorrhage
1.3 Haematemesis
1.1 Anaphylactic reaction

Eye disorders

19.1 Eyelid sensory disorder
17.1 Retinal artery occlusion
16.8 Ophthalmic migraine
16.4 Retinal migraine
15.4 Retinal vein occlusion
11.7 Lagophthalmos
11.5 Vitreous haemorrhage
11.5 Endocrine ophthalmopathy
10.7 Amaurosis fugax
10.7 Chorioretinopathy
10.5 Retinal tear
9.9 Dermatochalasis
9.9 Neurologic neglect syndrome
9.9 Eyelid contusion
9.2 Meibomian gland dysfunction
8.4 Visual snow syndrome
8.3 Dyschromatopsia
7.6 Cystoid macular oedema
7.6 Orbital swelling
7.3 Ocular discomfort
6.5 Ocular vascular disorder
6.4 Visual brightness
6.1 Eczema eyelids
6.1 Eye infection bacterial
6.1 Cyanopsia
6.1 Eyelid exfoliation
5.6 Chalazion
5.6 Episcleritis
5.3 Eyelid infection
5.3 Macular hole
5.3 Vitreous detachment
4.9 Hordeolum
4.8 Periorbital swelling
4.7 Hypoaesthesia eye
4.7 Periorbital pain
4.6 Metamorphopsia
4.3 Conjunctival haemorrhage
4.2 Angle closure glaucoma
4.2 Neovascular age-related macular degeneration
4.1 Vitreous floaters
4.0 Swelling of eyelid
3.9 Eye haemorrhage
3.9 Asthenopia
3.7 Eye colour change
3.6 IVth nerve paralysis
3.5 Eye contusion
3.3 Basedow's disease
3.3 Central vision loss
3.2 Eyelid irritation
3.1 Cataract
3.0 Optic ischaemic neuropathy
2.8 Giant cell arteritis
2.7 Retinal detachment
2.7 Macular degeneration
2.5 Tunnel vision
2.5 Iridocyclitis
2.5 Macular oedema
2.5 Photopsia
2.4 Altered visual depth perception
2.4 Sudden visual loss
2.4 Seasonal allergy
2.4 Blepharospasm
2.3 Blindness unilateral
2.2 Eyelid pain
2.2 Exophthalmos
2.1 Dry eye
2.1 Extraocular muscle paresis
2.0 Eye injury
2.0 Vision blurred
1.8 Eyelids pruritus
1.8 Blepharitis
1.7 Eyelid disorder
1.7 Sjogren's syndrome
1.7 Arthritis reactive
1.6 Visual impairment
1.6 Eye pain
1.5 Blindness transient
1.5 Abnormal sensation in eye
1.5 Eyelid rash
1.4 Photophobia
1.4 Eye inflammation
1.4 Blindness
1.4 Eye infection
1.4 Diplopia

Blood and lymphatic system disorders

149.7 Vaccination site lymphadenopathy
87.8 Blood loss anaemia
33.6 Normocytic anaemia
19.1 Metastases to lymph nodes
15.3 Splenic vein thrombosis
14.1 B-cell lymphoma
13.7 Hilar lymphadenopathy
13.4 Lymphadenopathy mediastinal
13.2 Splenic infarction
13.0 Anaemia macrocytic
11.5 Abdominal lymphadenopathy
9.0 Hypercoagulation
8.8 Nucleated red cells
8.4 Anaemia of chronic disease
8.4 Polycythaemia vera
7.6 Monoclonal gammopathy
7.6 Retroperitoneal lymphadenopathy
7.3 Neutrophilia
7.1 Febrile neutropenia
6.7 Factor V Leiden mutation
6.5 Heparin-induced thrombocytopenia
6.1 B-cell small lymphocytic lymphoma
6.1 Chronic myelomonocytic leukaemia
5.3 Haemorrhagic disorder
5.0 Splenic rupture
4.6 Chronic pigmented purpura
4.5 Iron deficiency anaemia
4.1 Macrocytosis
4.0 Lymph node pain
3.8 Diffuse large B-cell lymphoma
3.8 Benign lymph node neoplasm
3.8 Haemorrhagic diathesis
3.4 Chronic lymphocytic leukaemia
2.9 Injection site lymphadenopathy
2.9 Plasma cell myeloma
2.9 Anisocytosis
2.8 Sickle cell anaemia with crisis
2.7 Antiphospholipid syndrome
2.6 Eosinophilic oesophagitis
2.6 Polychromasia
2.5 Myelodysplastic syndrome
2.5 Lymphatic disorder
2.4 Mast cell activation syndrome
2.4 Disseminated intravascular coagulation
2.3 Polycythaemia
2.3 Lymphadenopathy
2.2 Acute myeloid leukaemia
2.0 Microcytic anaemia
2.0 Lymphoma
1.9 Pancytopenia
1.9 Lymphoedema
1.9 Thrombotic thrombocytopenic purpura
1.8 Haemophagocytic lymphohistiocytosis
1.8 Coagulopathy
1.7 Blood disorder
1.6 Lymphopenia
1.6 Autoimmune haemolytic anaemia

Injury, poisoning and procedural complications

149.7 Vaccination site lymphadenopathy
50.4 Vaccination site hypoaesthesia
48.3 Vaccine breakthrough infection
44.6 Vaccination site pruritus
24.4 Chillblains
20.6 Blue toe syndrome
19.1 Vaccination site movement impairment
18.7 Chest injury
16.0 Lumbar vertebral fracture
16.0 Immunisation anxiety related reaction
15.3 Vaccination site paraesthesia
14.9 Heart injury
14.1 Vaccination site scar
14.1 Vaccination site joint pain
14.0 Coronary artery dissection
13.8 Vaccination site mass
13.7 Haemoperitoneum
13.2 Vaccination site urticaria
11.5 Vaccination site erythema
11.5 Renal haemorrhage
11.5 Vaccination site hypersensitivity
10.7 Exposure via breast milk
10.6 Treatment noncompliance
10.5 Retinal tear
10.4 Oral blood blister
10.3 Toxic encephalopathy
10.3 Pelvic fracture
10.2 Vaccination site haemorrhage
9.9 Vaccination site pain
9.9 Coronary artery occlusion
9.9 Drug-induced liver injury
9.9 Eyelid contusion
9.8 Femur fracture
9.7 Myocardial oedema
9.2 Abdominal adhesions
9.2 Traumatic lung injury
9.0 Vaccination site discomfort
8.4 Injection site thrombosis
8.4 Sciatic nerve injury
8.4 Procedural haemorrhage
7.8 Incorrect product formulation administered
7.7 Spinal compression fracture
7.6 Haemothorax
7.6 Oesophageal rupture
7.6 Cystoid macular oedema
7.6 Vaccination site dryness
6.9 Maternal exposure during breast feeding
6.9 Wound dehiscence
6.9 Post procedural infection
6.9 Vaccination site discharge
6.9 Vein collapse
6.9 Vein rupture
6.9 Injection site muscle atrophy
6.9 Vaccination site rash
6.6 Post procedural haemorrhage
6.2 Hip fracture
6.1 Radius fracture
6.1 Catheter site haemorrhage
5.9 Vaccination site joint movement impairment
5.7 Vascular rupture
5.6 Vaccination site discolouration
5.5 Subarachnoid haemorrhage
5.3 Cerebrospinal fluid leakage
5.3 Intervertebral discitis
5.3 Postoperative wound infection
5.3 Vitreous detachment
5.1 Wound haemorrhage
5.0 Splenic rupture
4.9 Rib fracture
4.9 Foot fracture
4.8 Ankle fracture
4.7 Meniscus injury
4.6 Chemical burn
4.6 Thoracic vertebral fracture
4.5 Humerus fracture
4.4 Injection site muscle weakness
4.3 Spinal fracture
4.3 Incision site pain
4.3 Upper limb fracture
4.2 Skin wound
4.0 Subcutaneous emphysema
4.0 Vaccination site reaction
3.9 Subdural haemorrhage
3.9 Lower limb fracture
3.9 Eye haemorrhage
3.8 Oral contusion
3.8 Vaccination site bruising
3.7 Arthropod sting
3.6 Procedural pain
3.6 Chest crushing
3.6 Electric shock
3.6 Buttock injury
3.5 Brain herniation
3.5 Vaccination site irritation
3.5 Vaccination site scab
3.5 Eye contusion
3.5 Vaccination failure
3.5 Liver injury
3.4 Large intestine perforation
3.4 Poisoning
3.4 Vaccination site warmth
3.2 Wound infection
3.2 Tibia fracture
3.1 Vaccination site swelling
3.1 Peripheral nerve injury
3.1 Post concussion syndrome
3.1 Renal injury
2.9 Vaccination site vesicles
2.9 Injection site lymphadenopathy
2.9 Post procedural complication
2.8 Blood blister
2.8 Underdose
2.8 Vaccination site induration
2.8 Subdural haematoma
2.7 Burns second degree
2.7 Hand fracture
2.7 Retinal detachment
2.7 Craniocerebral injury
2.7 Food poisoning
2.7 Compression fracture
2.7 Transplant rejection
2.6 Limb injury
2.6 Endotracheal intubation complication
2.6 Expired product administered
2.6 Injection site indentation
2.5 Product storage error
2.5 Nerve compression
2.4 Tongue injury
2.4 Maternal exposure during pregnancy
2.3 Product label confusion
2.3 Incorrect dose administered
2.2 Recalled product administered
2.2 Alcohol poisoning
2.2 Nasal injury
2.2 Ligament sprain
2.2 Injection related reaction
2.1 Joint injury
2.1 Back injury
2.1 Ligament rupture
2.1 Accidental overdose
2.1 Bone contusion
2.1 Child maltreatment syndrome
2.1 Vaccination site inflammation
2.0 Facial bones fracture
2.0 Neck injury
2.0 Eye injury
2.0 Muscle strain
2.0 Immunisation reaction
2.0 Ear haemorrhage
1.9 Maternal exposure before pregnancy
1.9 Tooth loss
1.8 Bite
1.8 Muscle rupture
1.8 Epicondylitis
1.8 Joint dislocation
1.7 Road traffic accident
1.7 Extra dose administered
1.6 Product administration error
1.6 Injection site hypoaesthesia
1.6 Sunburn
1.5 Injection site paraesthesia
1.5 Fall
1.4 Wound
1.1 Injection site pruritus

Hepatobiliary disorders

38.2 Portal vein thrombosis
19.1 Bile duct stone
18.3 Biliary dilatation
17.9 Hypertransaminasaemia
15.3 Portal hypertension
13.7 Hepatic vein thrombosis
12.2 Hepatocellular carcinoma
11.8 Metastases to liver
11.5 Hepatic encephalopathy
11.5 Ischaemic hepatitis
9.9 Cholecystitis infective
9.9 Drug-induced liver injury
9.0 Hepatic lesion
6.9 Cirrhosis alcoholic
6.5 Varices oesophageal
6.4 Hepatic mass
6.1 Gallbladder enlargement
6.0 Biliary colic
5.8 Hepatic cyst
4.9 Hepatic pain
4.3 Hepatic cirrhosis
4.2 Biliary tract disorder
4.0 Cholelithiasis
3.8 Haemangioma of liver
3.8 Gallbladder oedema
3.8 Gallbladder polyp
3.5 Liver injury
2.9 Hyperammonaemia
2.8 Acute hepatic failure
2.7 Gallbladder disorder
2.4 Hepatic steatosis
2.4 Ascites
2.4 Cholangitis
2.3 Hypoalbuminaemia
2.1 Cholecystitis
1.9 Autoimmune hepatitis
1.7 Liver disorder

Endocrine disorders

27.5 Adrenal mass
24.9 Oligomenorrhoea
21.4 Ovulation disorder
14.2 Thyroid mass
11.6 Menstruation irregular
11.5 Endocrine ophthalmopathy
10.0 Hypomenorrhoea
9.0 Menstruation delayed
8.4 Thyroid pain
8.0 Thyroiditis subacute
7.6 Diabetic nephropathy
4.6 Adrenal adenoma
4.5 Goitre
4.2 Anovulatory cycle
4.2 Type 2 diabetes mellitus
4.1 Diabetic ketoacidosis
3.8 Hyperthyroidism
3.6 Thyroid cyst
3.4 Adrenocortical insufficiency acute
3.3 Basedow's disease
3.1 Glucose tolerance impaired
3.0 Amenorrhoea
2.8 Small fibre neuropathy
2.7 Diabetic neuropathy
2.7 Diabetic foot
2.5 Insulin resistance
2.5 Temperature regulation disorder
2.2 Exophthalmos
2.0 Thyroiditis
1.6 Autoimmune thyroiditis
1.5 Thyroid disorder
1.5 Hypothyroidism
1.3 Hypoglycaemia

Neoplasms benign, malignant and unspecified (incl. cysts and polyps)

29.8 Metastatic neoplasm
19.1 Metastases to lymph nodes
16.8 Metastases to central nervous system
14.1 B-cell lymphoma
13.0 Lung cancer metastatic
12.7 Breast cyst
12.2 Breast cancer metastatic
12.2 Hepatocellular carcinoma
11.8 Metastases to liver
11.5 Metastases to bone
9.2 Bladder cancer
9.2 Colon cancer
9.2 Invasive ductal breast carcinoma
9.2 Triple negative breast cancer
8.4 Bartholin's cyst
8.4 Oesophageal carcinoma
8.4 Polycythaemia vera
7.6 Metastases to spine
7.6 Small cell lung cancer
7.6 Monoclonal gammopathy
7.6 Uterine leiomyoma
7.3 Renal cyst
7.1 Pancreatic cyst
6.9 Renal cancer
6.9 Spinal cord neoplasm
6.9 Adenocarcinoma metastatic
6.5 Uterine cancer
6.1 Adenocarcinoma
6.1 B-cell small lymphocytic lymphoma
6.1 Chronic myelomonocytic leukaemia
6.1 Metastatic malignant melanoma
6.1 Recurrent cancer
6.1 Infected cyst
5.8 Hepatic cyst
5.7 Pancreatic carcinoma
5.7 Cyst rupture
5.3 Paranasal cyst
5.1 Large intestine polyp
4.6 Adrenal adenoma
4.6 Fibrocystic breast disease
4.2 Fibroadenoma of breast
4.1 Lung adenocarcinoma
3.9 Breast cancer female
3.8 Diffuse large B-cell lymphoma
3.8 Haemangioma of liver
3.8 Haemorrhagic ovarian cyst
3.8 Metastasis
3.8 Gallbladder polyp
3.8 Benign lymph node neoplasm
3.6 Thyroid cyst
3.5 Lung neoplasm malignant
3.4 Chronic lymphocytic leukaemia
3.4 Meningioma
3.3 Breast cancer
3.1 Prostate cancer
3.1 Squamous cell carcinoma of skin
2.9 Plasma cell myeloma
2.9 Haemangioma of skin
2.5 Myelodysplastic syndrome
2.3 Synovial cyst
2.3 Malignant melanoma
2.3 Ovarian cyst ruptured
2.2 Acute myeloid leukaemia
2.2 Polyp
2.0 Lymphoma
1.9 Squamous cell carcinoma
1.9 Lipoma
1.8 Haemophagocytic lymphohistiocytosis
1.7 Dermal cyst
1.5 Ovarian cyst

Gastrointestinal disorders

26.7 Abdominal hernia
26.0 Taste disorder
22.9 Mesenteric vein thrombosis
19.9 Pneumoperitoneum
19.1 Dental paraesthesia
16.8 Ageusia
15.0 Diverticulum intestinal
14.5 Defaecation disorder
13.7 Haemoperitoneum
13.7 Anaesthesia oral
13.0 Intra-abdominal fluid collection
12.2 Haemorrhoidal haemorrhage
12.2 Appendicitis
11.8 Dental discomfort
11.5 Oropharyngeal discomfort
11.5 Anal abscess
11.5 Abdominal lymphadenopathy
10.7 Gastritis erosive
10.7 Gingival abscess
10.7 Intestinal haemorrhage
10.4 Oral blood blister
10.3 Diverticulitis
9.9 Oesophageal dilatation
9.9 Peritonitis bacterial
9.9 Pelvic floor dysfunction
9.6 Appendicitis perforated
9.6 Colitis ischaemic
9.4 Tongue discomfort
9.2 Abdominal adhesions
9.2 Colon cancer
9.2 Large intestinal obstruction
8.5 Diverticulum
8.4 Gastric haemorrhage
8.4 Oesophageal carcinoma
8.4 Pulpitis dental
8.4 Tongue rough
8.2 Tongue erythema
7.7 Tongue pruritus
7.6 Tongue geographic
7.6 Pancreatic mass
7.6 Oesophageal rupture
7.6 Gastric infection
7.6 Retroperitoneal haematoma
7.6 Diverticular perforation
7.6 Retroperitoneal lymphadenopathy
7.6 Oral mucosal roughening
7.4 Upper gastrointestinal haemorrhage
7.1 Pancreatic cyst
6.9 Visceral pain
6.9 Anal rash
6.5 Varices oesophageal
6.3 Hyperaesthesia teeth
6.1 Hiatus hernia
6.1 Gingival recession
6.1 Mesenteric artery thrombosis
6.1 Colonic abscess
6.1 Appendicolith
6.1 Gastrointestinal wall thickening
5.9 Colitis microscopic
5.7 Pancreatic carcinoma
5.6 Gingival discolouration
5.3 Hypogeusia
5.2 Clostridium difficile colitis
5.1 Large intestine polyp
5.1 Cardiospasm
5.0 Large intestinal ulcer
5.0 Gingival ulceration
5.0 Hypoaesthesia teeth
5.0 Early satiety
5.0 Duodenogastric reflux
5.0 Pelvic fluid collection
4.9 Small intestinal obstruction
4.8 Coating in mouth
4.8 Intestinal ischaemia
4.6 Abdominal infection
4.6 Noninfective gingivitis
4.5 Aptyalism
4.4 Gingival blister
4.4 Burning mouth syndrome
4.3 Lip pruritus
4.3 Gingival discomfort
4.3 Oral lichen planus
4.2 Pancreatitis acute
4.2 Faeces soft
4.1 Mouth swelling
4.1 Palatal swelling
4.0 Umbilical hernia
4.0 Appendix disorder
4.0 Tongue haemorrhage
3.9 Discoloured vomit
3.8 Chronic gastritis
3.8 Oral contusion
3.8 Abscess intestinal
3.8 Gastroenteritis Escherichia coli
3.8 Large intestinal haemorrhage
3.8 Tongue dry
3.6 Paraesthesia oral
3.6 Pancreatitis necrotising
3.6 Pelvic discomfort
3.6 Lip erythema
3.5 Submaxillary gland enlargement
3.4 Large intestine perforation
3.4 Tooth abscess
3.4 Oral discomfort
3.4 Hypoaesthesia oral
3.4 Abdominal pain lower
3.3 Lip disorder
3.2 Angular cheilitis
3.2 Epigastric discomfort
3.2 Oesophageal pain
3.2 Oesophageal stenosis
3.1 Dysgeusia
3.1 Meniere's disease
3.1 Proctitis
3.1 Tooth infection
3.1 Gingival pruritus
3.1 Anal haemorrhage
3.0 Gingival swelling
3.0 Toothache
2.9 Colitis ulcerative
2.9 Pancreatic failure
2.9 Gingival pain
2.9 Crohn's disease
2.9 Enlarged uvula
2.8 Gastrointestinal inflammation
2.8 Dry throat
2.7 Tongue movement disturbance
2.7 Inguinal hernia
2.7 Food poisoning
2.7 Tongue eruption
2.6 Eosinophilic oesophagitis
2.6 Tongue blistering
2.6 Mastication disorder
2.5 Peritonitis
2.5 Oesophageal disorder
2.5 Lip pain
2.5 Oral pruritus
2.4 Ascites
2.4 Dry mouth
2.4 Gastrointestinal pain
2.4 Duodenal ulcer
2.4 Faecaloma
2.4 Oesophageal spasm
2.4 Oesophageal discomfort
2.4 Tongue injury
2.4 Colitis
2.4 Throat irritation
2.4 Rectal haemorrhage
2.4 Abdominal distension
2.3 Swollen tongue
2.3 Intestinal dilatation
2.3 Morning sickness
2.3 Oropharyngeal pain
2.2 Anorectal discomfort
2.2 Pelvic pain
2.1 Oral pain
2.1 Oesophageal achalasia
2.1 Defaecation urgency
2.1 Lip dry
2.0 Gingival bleeding
2.0 Glossodynia
2.0 Inflammatory bowel disease
2.0 Eructation
1.9 Gingival erythema
1.9 Tooth loss
1.9 Chapped lips
1.9 Haemorrhoids
1.8 Bowel movement irregularity
1.8 Dyschezia
1.8 Change of bowel habit
1.8 Dyspepsia
1.8 Pancreatitis
1.7 Incontinence
1.7 Tongue coated
1.7 Sjogren's syndrome
1.7 Odynophagia
1.7 Aphthous ulcer
1.7 Ileus
1.7 Gastrointestinal sounds abnormal
1.7 Tongue ulceration
1.7 Hiccups
1.6 Abdominal tenderness
1.6 Nausea
1.6 Gastrointestinal haemorrhage
1.6 Gastrooesophageal reflux disease
1.6 Abdominal discomfort
1.6 Irritable bowel syndrome
1.6 Oral herpes
1.5 Oral mucosal erythema
1.5 Retching
1.5 Dysphagia
1.5 Lip swelling
1.5 Glossitis
1.5 Oral mucosal blistering
1.4 Lip blister
1.4 Tongue discolouration
1.4 Stomatitis
1.4 Flatulence
1.4 Oral disorder
1.4 Oral mucosal eruption
1.4 Oral candidiasis
1.4 Cheilitis
1.3 Abdominal pain upper
1.3 Gastritis
1.3 Haematemesis
1.2 Diarrhoea
1.2 Hypophagia
1.1 Constipation
1.1 Abdominal pain

Pregnancy, puerperium and perinatal conditions

27.5 Suppressed lactation
15.3 Galactostasis
10.7 Exposure via breast milk
7.6 Pelvic girdle pain
6.9 Maternal exposure during breast feeding
6.9 Hydrops foetalis
6.1 Foetal chromosome abnormality
5.1 Birth defect
4.6 Cervical dilatation
4.0 Amniorrhoea
3.8 Tachycardia foetal
3.8 Foetal cardiac disorder
3.7 Lactation disorder
3.4 Breast engorgement
2.9 Uterine contractions during pregnancy
2.9 Anembryonic gestation
2.7 Antiphospholipid syndrome
2.6 Pregnancy
2.4 Maternal exposure during pregnancy
2.3 Morning sickness
2.0 Haemorrhage in pregnancy
1.9 Failure to thrive
1.9 Maternal exposure before pregnancy
1.9 Induced labour
1.5 Abortion spontaneous

Ear and labyrinth disorders

21.4 Vestibular migraine
11.1 Ear inflammation
9.9 Mastoid disorder
9.2 Paraesthesia ear
8.7 Inner ear inflammation
7.6 Mastoid effusion
6.1 Excessive cerumen production
5.9 Tinnitus
5.2 Ear discomfort
5.0 Vertigo positional
4.5 Eustachian tube disorder
3.9 Motion sickness
3.5 Sudden hearing loss
3.4 Middle ear effusion
3.3 Vestibular neuronitis
3.3 Eustachian tube obstruction
3.3 Deafness unilateral
3.2 Deafness bilateral
3.2 Inner ear disorder
3.1 Vertigo
3.1 Meniere's disease
3.0 Ear congestion
3.0 Eustachian tube dysfunction
2.9 Ear pruritus
2.9 External ear pain
2.8 Deafness neurosensory
2.5 Ear swelling
2.2 Deafness
2.2 Hyperacusis
2.0 Hypoacusis
2.0 Ear pain
2.0 Ear haemorrhage
1.8 Vestibular disorder
1.6 Otorrhoea

Skin and subcutaneous tissue disorders

44.6 Vaccination site pruritus
28.3 Hand dermatitis
24.4 Chillblains
16.6 Chronic spontaneous urticaria
15.3 Scar pain
14.8 Mechanical urticaria
14.1 Vaccination site scar
13.2 Vaccination site urticaria
13.0 Urticarial vasculitis
12.2 Hidradenitis
11.5 Vaccination site erythema
10.7 Perioral dermatitis
10.7 Lichen planopilaris
10.4 Oral blood blister
9.9 Dermatochalasis
9.9 Eyelid contusion
9.2 Skin discharge
7.6 Vaccination site dryness
7.6 Orbital swelling
7.4 Decubitus ulcer
7.1 Dyshidrotic eczema
6.9 Onycholysis
6.9 Rocky mountain spotted fever
6.9 Anal rash
6.9 Vaccination site rash
6.4 Sensitive skin
6.2 Circumoral swelling
6.1 Eczema eyelids
6.1 Metastatic malignant melanoma
6.1 Eyelid exfoliation
6.0 Psoriatic arthropathy
5.7 Gangrene
5.6 Skin sensitisation
5.6 Vaccination site discolouration
5.5 Genital ulceration
5.4 Urticaria chronic
5.3 Eyelid infection
4.8 Periorbital swelling
4.8 Drug reaction with eosinophilia and systemic symptoms
4.7 Capillary fragility
4.6 Urticaria cholinergic
4.6 Chronic pigmented purpura
4.4 Diffuse alopecia
4.3 Oral lichen planus
4.2 Erythromelalgia
4.2 Hypohidrosis
4.2 Intertrigo
4.2 Telangiectasia
4.2 Skin wound
4.1 Mouth swelling
4.0 Skin wrinkling
4.0 Swelling of eyelid
4.0 Subcutaneous emphysema
4.0 Skin texture abnormal
4.0 Skin weeping
3.8 Trichorrhexis
3.8 Vaccination site bruising
3.8 Burning feet syndrome
3.8 Vulval ulceration
3.6 Psoriasis
3.5 Vaccination site scab
3.4 Acne cystic
3.3 Lichen sclerosus
3.2 Angular cheilitis
3.2 Eyelid irritation
3.1 Skin swelling
3.1 Body tinea
3.1 Squamous cell carcinoma of skin
3.1 Vulvovaginal rash
3.0 Skin indentation
3.0 Hair texture abnormal
2.9 Vaccination site vesicles
2.9 Haemangioma of skin
2.8 Blood blister
2.8 Skin erosion
2.7 Burns second degree
2.7 Vaginal ulceration
2.7 Diabetic foot
2.6 Vitiligo
2.6 Injection site indentation
2.5 Rosacea
2.5 Pemphigus
2.4 Lichen planus
2.3 Night sweats
2.3 Swollen tongue
2.3 Guttate psoriasis
2.3 Malignant melanoma
2.3 Onychomadesis
2.2 Pemphigoid
2.2 Eyelid pain
2.2 Nail discolouration
2.2 Eczema nummular
2.2 Skin discomfort
2.1 Pityriasis rosea
2.0 Skin odour abnormal
2.0 Granuloma annulare
2.0 Pain of skin
2.0 Flushing
2.0 Piloerection
2.0 Alopecia areata
1.9 Allergy to chemicals
1.9 Pustule
1.9 Butterfly rash
1.9 Thrombotic thrombocytopenic purpura
1.8 Eyelids pruritus
1.8 Blepharitis
1.7 Eyelid disorder
1.7 Hyperhidrosis
1.7 Dermal cyst
1.6 Dermatitis acneiform
1.6 Sunburn
1.6 Hypoaesthesia
1.5 Skin haemorrhage
1.5 Cold sweat
1.5 Skin burning sensation
1.5 Lip swelling
1.5 Eyelid rash
1.4 Lip blister
1.4 Wound
1.4 Alopecia
1.4 Cheilitis
1.3 Dermatitis allergic
1.3 Paraesthesia
1.3 Skin induration
1.3 Swelling face
1.2 Rash pruritic
1.1 Injection site pruritus